Aberrant antibodies: don’t always trust what it says on the tin

Antibodies are proteins generated by the immune system capable of recognising short peptide fragments (known as epitopes) with a remarkably high degree of specificity. This specificity makes them a powerful tool for research, allowing us to identify, track, and quantify specific proteins in a wide range of assays. Monoclonal antibodies (mAbs) can be generated for…

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CD1b as a vaccine target for tuberculosis: A hidden GEM?

Tuberculosis is currently the most deadly infectious disease worldwide, killing an estimated 1.7 million people in 2016. The only licensed vaccine currently available is BCG, which is only 70% effective. While most vaccines work by inducing antibodies, mycobacterium tuberculosis (or Mtb for short) hides inside cells, preventing antibodies from reaching it. T cells, which help…

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