A group of researchers has discovered that the interstitial space surrounding cells in numerous tissues such as the lungs, gut, dermis and blood vessels has a unique structure that hasn’t been described before. It has been observed that this space is made up of multiple fluid-filled sinuses that form a network through which interstitial fluid…
Multi-drug resistance is the main challenge for chemotherapy – it is the leading cause of tumour recurrence and cancer metastasis. The root of the problem: efflux pumps on the cell surface which serve to protect a cell by pumping out unwanted toxic substances. Unfortunately, these come as a disadvantage when targeting cancer cells with drugs….
The current UK population consumes an average of about 8.5g/day of salt, more than 2g/day above the maximum recommended daily amount. This is worrying given its well-known health implications. Salt raises blood pressure, increasing risk of heart disease and stroke. One in three of UK adults have high blood pressure, and as many people are…
Oxford University and Public Health England (PHE) have lead an international team of scientists in an analysis of HIV migration patterns across the Ukraine. This study, which used genomic data to reconstruct the spread of the virus, has shown how geopolitical events have helped to conduct the virus to regions where it is more likely…
When we experience a particularly bad flu season, like the current one, the question of how a single disease can vary so wildly is often raised. The answer lies in the simple fact that the virus copies its RNA genome with very poor accuracy which means that the virus is constantly mutating and evolving to…
Alzheimer’s disease is a major global health problem, with the number of people with the disease in the UK expected to double by 2050. Efforts to develop an effective treatment have not yet been successful as we don’t properly understand what causes it. What do we already know about Alzheimer’s? One of the key features…
A recent study, published on Nature Neuroscience, lays groundwork for potential development of first neurobiologically-based therapy for patients with autism spectrum disorders (ASD). This research from the O’Donnell Brain Institute in the U.S. explored a specific area within the right cerebellum, called CrusI. Whilst cerebellar abnormalities in ASD patients were known for some time, the…
Tuberculosis is currently the most deadly infectious disease worldwide, killing an estimated 1.7 million people in 2016. The only licensed vaccine currently available is BCG, which is only 70% effective. While most vaccines work by inducing antibodies, mycobacterium tuberculosis (or Mtb for short) hides inside cells, preventing antibodies from reaching it. T cells, which help…
People live messy lives: they make complex choices about what to eat, who to start a family with, and generally how to live their lives. Mice on the other hand are much simpler. They can live in a lab where their diet, mating and behaviour can be carefully monitored and controlled. This makes it far…
Recent developments in gene editing technologies have caused the dialogue surrounding the prospect of ‘designer babies’ to reach a new pitch. Research recently published in Protein and Cell might be bringing us one exhilarating – or terrifying – step closer to making that prospect a reality. The group behind the paper, based at Sun Yat-sen…
